?????? ?????? ??????? ?????? ?????? ??????? ????? ??????????? ?????: ?? ?? ????? ??? ???????? ??????? ??????? ????????In sufferers with creatinine clearance prices a lot less than fifty mL/min, begin OPANA ER inside the opioid-naïve patient Along with the 5 mg dose. For people on prior opioid therapy, start off OPANA ER at 50% lessen compared to